DUAL IMMUNOHISTOCHEMISTRY WITH CD34 WILL ENHANCE THE C4d SENSITIVITY AND SPECIFICITY ON RENAL ALLOGRAFT BIOPSY
نویسندگان
چکیده
منابع مشابه
Comparison of C4d immunostaining methods in renal allograft biopsies.
Immunostaining of renal allograft biopsies for C4d deposition has become an important diagnostic tool in the recognition of humoral-mediated graft rejection. The majority of studies have been performed on frozen tissue sections with one of several commercially available antibody reagents. However, only a single small series that compared reagents or methods, including staining of formalin-fixed...
متن کاملUse of ultrasound for renal allograft biopsy.
Biopsy of the transplanted kidney may provide useful diagnostic and prognostic information [ljJ. Several biopsy methods have been developed to minimize the risk of damaging the solitary functioning renal allograft. Each method has inherent advantages and disadvantages. Recently, ultrasonography has provided a safe and efficient means of guidance for biopsy of native kidneys [2-6]. Because of pr...
متن کاملC4d staining in renal allograft biopsies with early acute rejection and subsequent clinical outcome.
BACKGROUND AND OBJECTIVES Diffuse C4d staining in peritubular capillaries (PTCs) during an acute rejection episode (ARE) is the footprint of antibody-mediated rejection. In current clinical practice, diffuse C4d+ staining during acute rejection is regarded as an inferior prognostic sign. This case-control study investigated the prognostic role of mere C4d staining for graft outcome during an AR...
متن کاملImmunohistochemical Scoring of C4d in Egyptian Patients with Chronic Renal Allograft Dysfunction
C4d is a degradation product of complement component C4. Since the beginning of the current century, C4d has been used as a marker of acute antibody mediated rejection in renal allograft and considered as an ominous portent for poor graft survival. The ninth Banff meeting emphasized the value of C4d in renal allograft biopsy assessment and adopted a grading system for the staining degree of C4d...
متن کاملCapillary Deposition of Complement C4d and C3d in Chinese Renal Allograft Biopsies
BACKGROUND C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear. METHODS 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clini...
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ژورنال
عنوان ژورنال: Journal of Evolution of Medical and Dental Sciences
سال: 2016
ISSN: 2278-4748,2278-4802
DOI: 10.14260/jemds/2016/1480